Our work “Reactive Oxygen Species Scavenging Capacity of Functional Fullerenes in Solution and in Macrophage Cells” is accepted by ACS Applied Nano Materials!
The work is led by Rohin Biswas, and is done in collaboration with Profs. Ki-Bum Lee of Rutgers, Jin Li and Xudong Li of University of Virginia. We synthesized eight representative water-soluble fullerene derivatives and compared their radical scavenging properties via electron paramagnetic resonance in solution and antioxidative capacity in the H2O2-treated RAW 264.7 macrophage cell model. Through this systematic study, we identified multiple key parameters contributing to their radical scavenging and antioxidative effects, including the number and identity of functional groups on the C60 cage, the size of aggregates, and their cellular uptake in RAW 264.7 cells. Very excitingly, the structurally well-defined hexakisadduct of fullerene shows antioxidant behavior for the first time.
The full article is linked here.
Zhang Lab @ Rutgers CCB 